The song gained worldwide success around the world reaching top five in the United States and in Belgium, like their previous single it debuted at number one in New Zealand and in the United Kingdom and reached top three in Australia, Ireland and the Netherlands.

The song gave the Dolls a Grammy nomination at the 49th Annual Grammy Awards for the Best Pop Performance by a Duo or Group with Vocals but lost to Black Eyed Peas "My Humps". The song has been performed several times on television including the remix with Avant.

The was directed by Nigel Dick The video was shot over two days in different places in Los Angeles including Orpheum Theatre.

In an interview at MTV News Dick talked about directing the music video, he said the main theme of the video was:

He continued saying:

The music video begins with the group at a hotel being awoken by someone knocking on the door. The Pussycat Dolls begin to pack their belongings, then walk to their tour bus, stopping to sign autographs for fans on the way. The video continues to show footage of the girls on the bus, in dance rehearsals and practicing the song "Stickwitu". The video ends with group coming out of a back entrance of a building posing for some pictures. Throughout the video, the Pussycat Dolls are seen talking on Nokia mobile phones, presumably to their partners.

"Stickwitu" entered the US Billboard Hot 100 at number eighty-five and ascended to number sixty-seven in its second week. By its fourth week, "Stickwitu" had already become the group's second top 40 single and by its ninth week had peaked at number five where it spent three non-consecutive weeks. "Stickwitu" also peaked at number-one for two weeks on the Pop 100 Airplay, and number-two on the Billboard Pop 100 charts respectively. "Stickwitu" also charted on the Billboard Hot R&B/hip-hop songs, and has peaked at number sixty-three.

In the United Kingdom, "Stickwitu" debuted and peaked at number-one for two consecutive weeks, becoming the group's second consecutive UK number one single. "Stickwitu" spent 6 weeks within the top ten, and remained on the chart for a total of 17 weeks . In Canada, "Stickwitu" peaked at number fifteen on the Canadian BDS airplay chart and at number-nine on the Canadian Singles Chart, and is to date the group's second top ten single, and also their second most successful song on this chart.

"Stickwitu" was also a major success in Oceania. In Australia, "Stickwitu" debuted at number-three on the Australian ARIA Singles Charts and eventually peaked at number-two for two consecutive weeks, and was certified Platinum by ARIA for sales in excess of 70,000 . "Stickwitu" appeared on the ARIA Year-End Singles Chart the following year and was ranked at number twenty-nine. It was one of four releases by the group to have made this chart, with the others being its successors; "Beep", "Buttons" and "I Don't Need A Man". In New Zealand, "Stickwitu" peaked at number one for two non-consecutive weeks on the New Zealand RIANZ Singles Chart, one week more than its predecessor, "Don't Cha" had spent at number one, and becoming the group's second consecutive number one hit. "Stickwitu" was ranked at number-fifteen on the Year-End RIANZ Singles Chart for 2006 .

"Stickwitu" was also a success in Europe. "Stickwitu" was most successful in the Netherlands where it peaked at number-two for two consecutive weeks, becoming the group's second consecutive single to peak at number-two . "Stickwitu" was also successful elsewhere in Europe reaching the top ten in Switzerland, Belgium, Norway and Italy. It also peaked within the top twenty in Germany, Austria and France, as well as the top 40 in Sweden. "Stickwitu" peaked at number-four on the European Hot 100 following its success across Europe.